BioFoam is a proprietary CryoLife developed product that contains a protein Hydrogel biomaterial with an expansion agent which generates a mixed-cell foam. The foam creates a mechanical barrier to decrease blood flow and pores for the blood to enter, leading to cellular aggregation and enhanced hemostasis. BioFoam has been demonstrated to be a minimal activator of the intrinsic coagulation pathway. The product characteristics associated with clinical effectiveness include the adherence of the product to the surface of the tissue (cross-linking) and expansion of the product. BioFoam is provided in a double-barreled container that is prefilled with solutions of protein and a cross-linker. Upon mixing of the two solutions in the applicator tip attached to the container, both the foaming and cross-linking reactions begin. The foamy liquid expelled from the tip is adhesive, but sets up within seconds as soft foam. BioFoam is CE certified for the use as an adjunct in the sealing of abdominal parenchymal tissues (liver and spleen) when cessation of bleeding by ligature or conventional methods is ineffective or impractical.